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Scholars Rebecca Safran and Tin Tin Su recognized by the American Association for the Advancement of Science for excellence in research, teaching and interpreting science to the public

Rebecca Safran, a professor of ecology and evolutionary biology who has led groundbreaking research on the evolution of new species, and Tin Tin Su, professor and chair of molecular, cellular and developmental biology whose research is leading to novel cancer therapies, have been named .

The AAAS fellowship is among the highest honors in the scientific community, recognizing a distinguished cohort of scientists, engineers and innovators who “have been recognized for their achievements across disciplines, from research, teaching and technology to administration in academia, industry and government, to excellence in communicating and interpreting science to the public,” AAAS officials note.

“This year’s AAAS Fellows have demonstrated research excellence, made notable contributions to advance science and delivered important services to their communities,” says Sudip S. Parikh, AAAS chief executive officer and executive publisher of the ��������Գ�����family of journals. “These Fellows and their accomplishments validate the importance of investing in science and technology for the benefit of all.”

Rebecca Safran is a professor of ecology and evolutionary biology who has led groundbreaking research on the evolution of new species.

A study of swallows

Safran, whose passion for biology took root in a plant taxonomy class during her undergraduate studies at the University of Michigan, and her research team, study , focusing on the causes and consequences of individual variation across different scales of time and space.��

Because studying the formation of new species can be difficult—given that most species are millions of years old and what caused them to diverge from their ancestors often can’t be determined—Safran and her team study barn swallows, a very closely related group of populations of migratory birds that are currently diverging. This allows Safran and her team to study the process of speciation in real time.

Safran won a National Science Foundation Early Career Development award to study speciation in barn swallows across their entire, expansive breeding range throughout the Northern Hemisphere and Middle East. During the COVID-19 pandemic, when it wasn’t possible to conduct research in other countries, Safran and her research team began focusing on the rapid decline in the population of barn swallows and its implications. For their work, Safran and team study the birds using a highly integrative approach including behavioral, physiological and genetic perspectives.

Among other discoveries, Safran and her team found that sexual selection, or the process by which organisms choose mates based on traits they find attractive, drives the emergence of new species. Her team’s research has been published in more than 120 peer-reviewed journals, including��Science, Nature�����Ի���Current Biology. She also co-edited a recent book on speciation (2024, Cold Spring Harbor Press).

“None of this work is possible without the incredible collaboration with students, colleagues at CU and around the world, private landowers who allow us to study populations of barn swallows on their properties and continuous funding support by the National Science Foundation and other agencies,” Safran says. “I am especially honored to have worked with so many talented undergraduate, graduate and postdoctoral students."

Studying fruit flies to treat cancer

Su, who attended Woodstock School in Mussoorie, Uttarakhand, India, credits her experiences there, in part, with that her ideal environment is one in which “you do respect the elders or people who have had more experience or authority. But at the same time, if it doesn't seem right, you question it.”

Tin Tin Su is a professor and chair of molecular, cellular and developmental biology whose research is leading to novel cancer therapies.

Throughout her career, Su and her research colleagues have sought to develop new ways of attacking cancer. Through research on how tissues and organs in fruit flies regenerate after being damaged by X-rays, they synthesized the chemical SVC112, which helps prevent cancer cells from regrowing following radiation exposure. Su and her colleagues focused on the fruit fly because this insect shares more than 70% of disease-relevant genes with humans.

SVC112 is based on the chemical bouvardin found in the firecracker bush (Bouvardia ternifolia) that grows in the Southwest United States and Mexico. Su and her colleagues discovered that bouvardin can prevent regeneration of tissues in fruit flies.

More recently, Su, who also is a member of the CU Cancer Center, and her colleague Antonio Jimeno, co-leader of the CU Cancer Center’s��Developmental Therapeutics Program, used SVC112 to target cancer stem cells in head and neck cancers. They are in the process of applying to the FDA to test SVC112 in human trials.

Su also has participated in the ���Ҵ�ý�ƽ������ Community Perspectives Program, conducting outreach in several rural Colorado communities that led to a research collaboration with Colorado State University Pueblo to assess the effect of heavy metals on the genome in��fruit fly��and human cells.

“I do what I do because I love science,” Su says. “The potential to help cancer patients in Colorado and beyond makes it even better. So, to be named a AAAS Fellow is really the cherry on top!”

���Ҵ�ý�ƽ������ the AAAS Fellowship

The AAAS began naming fellows annually in 1874, people nominated by the AAAS Council to recognize those whose “efforts on behalf of the advancement of science or its applications are scientifically or socially distinguished.”

Safran and Su join a cohort of more than 80 ���Ҵ�ý�ƽ������ faculty members who previously received the honor, as well as a broader cadre that includes Thomas Edison, W.E.B DuBois, Maria Mitchell, Steven Chu, Ellen Ochoa and Irwin M. Jacobs. ��

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