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JILA Fellows Dr. Tom Perkins and Dr. Konrad Lehnert both received medals from the Department of Commerce last night at the Ronald Reagan Amphitheater in Washington, D.C. Dr. Perkins received the Gold Medal, which is the highest honorary award given by the United States Department of Commerce, or DOC. Perkins was recognized for creating the world’s best atomic force microscope tailored to biological measurements. This device can “grab” onto biological molecules, such as proteins, and measure the tiny forces involved in their folding and unfolding.

Fellow Tom Perkins has won a 2017 Governor’s Award for High-Impact Research. Perkins will receive the award from Governor John Hickenlooper at an event sponsored by the CO-LABS consortium at the Denver Museum of Nature and Science on October 5, 2017. This year’s ninth annual event will honor Colorado’s top scientists and engineers for projects having a significant impact on society.

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision biomechanical measurements up to 100 times faster than previously possible––obtaining useful information in hours to days rather than weeks to months.

The Perkins group continues to extend the performance of its unique Atomic Force Microscope (AFM) technology, revealing for the first time a dozen new short-lived intermediate states in the folding and unfolding of a membrane protein that controls the exchange of chemicals and ions into and out of living cells. Measuring the energetics and dynamics of membrane proteins is crucial to understanding normal physiology and disease, and the Perkins group’s observation of multiple new folding/unfolding states shines new light on these cellular “gatekeepers.”