Damrauer /rasei/ en A New Dial for Controlling Light-Driven Chemistry /rasei/2026/07/21/new-dial-controlling-light-driven-chemistry <span>A New Dial for Controlling Light-Driven Chemistry</span> <span><span>Daniel Morton</span></span> <span><time datetime="2026-07-21T11:45:04-06:00" title="Tuesday, July 21, 2026 - 11:45">Tue, 07/21/2026 - 11:45</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2026-07/Thumbnail%402x.png?h=e91e470d&amp;itok=qTNfDoSG" width="1200" height="800" alt="Illustration of the catalyst for Single Electron Transfer highlighted in this work"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/177"> News </a> <a href="/rasei/taxonomy/term/170"> Publication Highlight </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/350" hreflang="en">SUPRCAT</a> </div> <a href="/rasei/our-community">Daniel Morton</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><p class="lead">RASEI Fellow <a href="/rasei/niels-damrauers-rasei-engagement" rel="nofollow">Niels Damrauer</a> (University of Colorado Boulder) and a multidisciplinary team initiated by Professor <a href="https://wickens.chem.wisc.edu/zach/" rel="nofollow">Zach Wickens</a> at the University of Wisconsin Madison just found a new way to control which molecules react in light-driven chemistry. The key to unlocking this new pathway? Focus on what happens after the reaction starts, not before.&nbsp;</p><h3><strong>SET: A powerful reaction for building organic molecules, such as medicines and materials</strong></h3><p>This type of reaction, called single electron transfer (SET), is one of the most useful tools in modern chemistry. It can be initiated by swapping in light or electricity instead of heat, making it more energy efficient and less prone to generating waste products. But there have always been some limitations with SET. Some molecules just don’t want to accept an electron, particularly when there are other types of molecules nearby that do the reaction faster, meaning that they’ve been locked out of this chemistry, until now. The new study, published in <a href="https://www.nature.com/articles/s41586-026-10897-7" rel="nofollow">Nature</a> with collaborators Zachary Wickens from the University of Wisconsin-Madison and <a href="https://patonlab.com/robert-paton/" rel="nofollow">Robert Paton</a> at Colorado State University, opens the door to reactions that were previously impossible.&nbsp;</p></div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><h3><strong>How Single Electron Transfer Works</strong></h3><p>One molecule, commonly after absorbing light, transfers an electron to another, triggering a reaction. Researchers have previously controlled the outcome of the reaction by picking molecules based on how ‘eager’ they are to grab, or accept, that electron. The molecule most ready to accept the electron wins. This approach has produced a wide range of really impressive chemistry, but it leaves out any molecule that isn’t ‘interested’ in the electron to begin with.&nbsp;</p><h3><strong>Identifying an opportunity</strong></h3><p>Every SET reaction actually has two steps, not one. First, an electron is transferred from a donor molecule to an acceptor molecule. Then, it has an option, it can either go forward to trigger a reaction, or it can go backward, undoing the first step. It is reversible. Chemists have always focused on controlling the first electron transfer. This team asked what would happen if they found a way to control the second electron transfer instead.</p><h3><strong>An extreme electron donor</strong></h3><p><span>To test this idea the researchers built what they call a “super-potent photoreductant”. It’s a light-activated catalyst that hands out electrons to almost every nearby molecule, good at accepting or not. In this particular research, the reductant is a solvated electron released from a photoexcited catalyst. Damrauer and his student Arindam Sau used time resolved spectroscopies to disentangle mechanism and identify conditions, such as the wavelength for photoexcitation, where catalysts could function. Damrauer notes, “By analyzing time-resolved signals in our experiment, my student Arindam was able to find colors for photoexcitation where the electron, the reductant, would be released deeper into the solvent, thereby affording it time to do its work in reducing the substrate molecules in solution.” But shouldn’t this reducing potency wipe out selectivity entirely? If every molecule gets an electron, which one ‘wins’?</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2026-07/DSC03275.jpg?itok=kpQdt2Nd" alt="Picture of two of the authors" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> <span class="media-image-caption"> <p>RASEI Fellow Niels Damrauer at the graduation of one of the lead researchers Arindam Sau (Boulder, CO, 2026).&nbsp;</p> </span> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><h3><strong>Reversibility is the key</strong></h3><p>The opportunity comes down to the second electron transfer. If a molecule accepts an electron, but doesn’t react quickly, the electron slips back to the catalyst and molecule floats away unchanged. If the molecule does react quickly, in a non-reversible way, the electron doesn’t go back to the catalyst and the reaction moves forward. Selectivity now depends on how reversible the electron transfer is, not how easy the initial electron transfer was.&nbsp;</p><h3><strong>Building a model reaction to test the hypothesis</strong></h3><p>The team tested this using a mixture of two molecules side by side: One that accepts electrons readily, but also gives them back easily, and one that ‘reluctantly’ accepts electrons, but then holds on tight once it does through a structural change. Under the old rules, the ‘eager’ electron acceptor would win. Under the new rules the ‘reluctant’ one wins, moving forward along the reaction pathway, leading to the formation of a new product that would not have been otherwise possible. Through a series of experimental explorative and optimization reactions the team were able to confirm that this selectivity preference held across a broad range of related molecules, not just the one test case.&nbsp;</p><h3><strong>No molecules left behind</strong></h3><p><span>With this works chemists now have a new dial to turn. Molecules that were previously incompatible with this efficient, light-driven chemistry are now available. This opens new pathways for building medicines and advanced materials, using less energy and creating less waste along the way.</span></p></div> </div> </div> </div> </div> <div>JULY 2026</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div> <div class="imageMediaStyle large_image_style"> <img loading="lazy" src="/rasei/sites/default/files/styles/large_image_style/public/2026-07/Hero%402x.png?itok=EjyA_162" width="1500" height="329" alt="Illustration of the central chemical reaction for this work"> </div> </div> <div>On</div> <div>White</div> Tue, 21 Jul 2026 17:45:04 +0000 Daniel Morton 1623 at /rasei Structure–Property–Performance Relationships of Tetra-Alkylated Phenazine Photoredox Catalysts in Organocatalyzed Atom Transfer Radical Polymerization /rasei/2025/11/03/structure-property-performance-relationships-tetra-alkylated-phenazine-photoredox <span>Structure–Property–Performance Relationships of Tetra-Alkylated Phenazine Photoredox Catalysts in Organocatalyzed Atom Transfer Radical Polymerization</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-11-03T11:34:58-07:00" title="Monday, November 3, 2025 - 11:34">Mon, 11/03/2025 - 11:34</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-12/2025_11_03_Macromolecules_Thumbnail.png?h=d95abdc4&amp;itok=PO4AITNW" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/43"> Publication </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/269" hreflang="en">Energy Applications</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/350" hreflang="en">SUPRCAT</a> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> </div> </div> </div> </div> <div>MACROMOLECULES, 2025, 58, 22, 12241-12249<br> November 2025</div> <script> window.location.href = `https://doi.org/10.1021/acs.macromol.5c02569`; </script> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Mon, 03 Nov 2025 18:34:58 +0000 Daniel Morton 1459 at /rasei Organocatalyzed Atom Transfer Radical Polymerization (O-ATRP) Using a Super-Reducing Photoredox Catalyst /rasei/2025/10/08/organocatalyzed-atom-transfer-radical-polymerization-o-atrp-using-super-reducing <span>Organocatalyzed Atom Transfer Radical Polymerization (O-ATRP) Using a Super-Reducing Photoredox Catalyst</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-10-08T17:34:02-06:00" title="Wednesday, October 8, 2025 - 17:34">Wed, 10/08/2025 - 17:34</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-10/2025_10_08_Angew.png?h=c4e54fe5&amp;itok=OnqvmxE6" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/43"> Publication </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/280" hreflang="en">Computational Modeling</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/269" hreflang="en">Energy Applications</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/350" hreflang="en">SUPRCAT</a> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> </div> </div> </div> </div> <div>ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, e202517641<br> October 2025</div> <script> window.location.href = `https://doi.org/10.1002/anie.202517641`; </script> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Wed, 08 Oct 2025 23:34:02 +0000 Daniel Morton 1430 at /rasei Unlocking a Cleaner Way to Do Chemistry /rasei/2025/09/30/unlocking-cleaner-way-do-chemistry <span>Unlocking a Cleaner Way to Do Chemistry</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-09-30T09:11:48-06:00" title="Tuesday, September 30, 2025 - 09:11">Tue, 09/30/2025 - 09:11</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-10/2025_10_Light_Thumbnail.jpg?h=4362216e&amp;itok=yc-FkKoF" width="1200" height="800" alt="Illustration of a reaction vessel in a light reactor"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/177"> News </a> <a href="/rasei/taxonomy/term/170"> Publication Highlight </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/51" hreflang="en">Barlow</a> <a href="/rasei/taxonomy/term/314" hreflang="en">Biolec</a> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/160" hreflang="en">Dukovic</a> <a href="/rasei/taxonomy/term/315" hreflang="en">EPN</a> <a href="/rasei/taxonomy/term/50" hreflang="en">Marder</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/145" hreflang="en">Neale</a> <a href="/rasei/taxonomy/term/81" hreflang="en">Reid</a> <a href="/rasei/taxonomy/term/140" hreflang="en">Rumbles</a> <a href="/rasei/taxonomy/term/350" hreflang="en">SUPRCAT</a> </div> <a href="/rasei/our-community">Daniel Morton</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><p class="hero"><em><strong>Taking the heat out of chemical manufacturing</strong></em></p><p class="lead"><span>For nearly two centuries chemists have relied on a simple principle when building molecules and materials: to make something new you have to apply energy, sometimes in the form of chemical energy, but most often in the form of heat.&nbsp;</span></p><p><span>From producing plastics to creating life-saving medicines, many of the chemical reactions that form the foundation of our modern world are driven by thermal energy, often generated by burning fossil fuels. This approach, while effective, is often incredibly energy-intensive and can lead to a host of other issues, from unwanted byproducts to a large carbon footprint. In essence it is like using a sledgehammer to build a delicate piece of furniture, while it might get the pieces together, it’s inefficient, causes unnecessary damage, and creates a lot of waste in the process.</span></p><p><strong>But what if there was a better way? What if we could take the heat out of chemical manufacturing and use a more precise, sustainable energy source?</strong></p><p>RASEI fellows are part of a growing wave of research that is doing just that by using light to drive chemical transformations. This isn’t about using light to just heat things up, it’s about harnessing the specific energy of photons to activate molecules in a targeted and efficient way. This approach, known as photocatalysis, is unlocking a cleaner, more controlled way to build the molecules we need. It is poised to transform everything from the creation of pharmaceuticals to the development of new and sustainable materials and plastics.</p><p>The shift to light-driven chemistry is not merely an academic exercise; it is a critical step toward a more sustainable and efficient industrial future. RASEI researchers, working across a range of national collaborations, have published more than 15 research papers in the past year, reflecting their commitment to innovation in this space. The research approaches the problem from a range of perspectives, exploring new chemical pathways and understanding the factors that control the efficiencies of these reacting.</p><p>The benefits of collaborative research the brings together a range of approaches to solve problems together is well illustrated in this roundup of recent research, including highlights from some large national collaborations, including contributions from U.S. Department of Energy funded Energy Frontier Research Centers (the Bio-inspired Light-Escalated Chemistry Center (<a href="/rasei/biolec" rel="nofollow">BioLEC</a>) and the Ensembles of Photosynthetic Nanoreactors (<a href="/rasei/epn" rel="nofollow">EPN</a>)), and a National Science Foundation funded Center for Chemical Innovation (The Center for Sustainable Photoredox Catalysis (<a href="/rasei/suprcat" rel="nofollow">SuPRCat</a>))</p><p>The summaries that follow provide a glimpse into this exciting work, detailing some of our latest discoveries and describing some of the tangible ways we are using light to create cleaner, more effective, and sustainable chemical processes.&nbsp;</p><p>&nbsp;</p><h2><strong>Recent Research Highlights</strong></h2><hr></div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><h3><strong>Shining new light on an old problem: Breaking down ‘Forever Chemicals’ and building the next generation of materials</strong></h3><p>DOI: <a href="https://doi.org/10.1038/s41586-024-08327-7" rel="nofollow">https://doi.org/10.1038/s41586-024-08327-7</a></p><p class="lead"><em>Using a new catalyst and visible light, researchers have developed a chemical “scalpel” to degrade persistent pollutants and enable new, more precise chemical reactions.&nbsp;</em></p><p>The global challenge of “forever chemicals” has made the headlines for years. The carbon-fluorine (C–F) bond is one of the strongest in all of chemistry. For decades the sheer strength of the C–F bond has been a blessing and a curse. This incredible strength is what makes “forever chemicals”, like PFAS, so stable and useful in everything from non-stick pans to waterproof clothing but is also the reason that they are nearly impossible to break down. This has been a major contributor to the growing plastic waste crisis, and a key reasons for these compounds to be now known as one of the hardest pollutants to remove from the environment. A recent collaborative study, including <a href="/rasei/niels-damrauers-rasei-engagement" rel="nofollow">RASEI Fellow Niels Damrauer</a>, has a new solution for this problem. Development of a new catalyst that acts like a chemical scalpel, using blue light to precisely sever this famously inert bond. This approach not only offers a new way to degrade these persistent pollutants but also opens the door to using what were previously considered unreactive fluorinated molecules as building blocks for new chemical transformations and products.</p><p>This study is an illustrative example of a modern, collaborative approach to chemical innovation, as part of the NSF funded Center for Sustainable Photoredox Catalysis (<a href="/rasei/suprcat" rel="nofollow">SuPRCat</a>). The research team came at the problem from two different angles: computational modeling and hands-on experimentation. The computational chemists first used powerful simulations to design and predict the behavior of a new organic catalyst. This helped them understand exactly how the catalyst could use low-energy, visible blue light to act as our "chemical scalpel," targeting and breaking the C–F bonds without the need for intense heat.</p><p>With this knowledge, the experimental chemists then created the catalyst in the lab. They showed that it could precisely snip the C-F bonds in a variety of molecules, demonstrating it was capable of both degrading persistent pollutants like PFAS and building new chemical structures that were previously difficult to construct.</p><p><span>The success of this research with a simple, abundant energy source like visible light shows that chemical reactions don’t have to be energy intensive. This research describes the power of precise, light-driven chemistry. By designing a catalyst that can target and activate some of the toughest bonds in chemistry, this team has not only revealed a potential path forward for degrading PFAS, but also demonstrated a new tool for chemists to build molecules in a cleaner and more energy efficient way.</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Damrauer_PFAS-01.png?itok=XwEOQVzU" alt="Figures from the paper, including functionalization and decomposition of PFAS chemicals" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><hr><p>&nbsp;</p></div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 2"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-content-media ucb-article-content-media-left col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Neale_Detail-01.png?itok=81ZD0GZe" alt="Figures from paper describing new molecular bridge" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><h3><strong>A Chemical Blueprint for Turning Sunlight and Carbon Dioxide into Fuel</strong></h3><p>DOI: <a href="https://doi.org/10.1021/acsmaterialsau.5c00010" rel="nofollow">https://doi.org/10.1021/acsmaterialsau.5c00010</a></p><p class="lead"><em>Combining computational design and experimental research, scientists have engineered a well-aligned connection between two materials, creating a more efficient pathway for clean energy.&nbsp;</em></p><p>The search to create carbon-neutral fuels from sunlight and carbon dioxide (CO<sub>2</sub>) is one of the most exciting frontiers in sustainable energy. However, it is not enough to simply find a catalyst that can do the job, the real challenge lies in designing a system where all the components work in harmony. Imagine having two brilliant devices that are designed to work together, but they just can’t quite “talk” to each other. One is an incredible light sensitive material that captures sunlight, and the other is a special catalyst that can turn CO<sub>2</sub> into fuel. Previous research has found that when you bring these two components together their electronic energies were mismatched, causing poor ‘communication’ between the components, leading to the overall system being inefficient. Research led by&nbsp;<a href="/rasei/nathan-neales-rasei-engagement" rel="nofollow"><span>RASEI Fellow Nate Neale</span></a><span> uses a combination of advanced computational modeling and sophisticated experimentation to engineer an aligned electronic “bridge” to better connect the two materials, revealing a more efficient communication pathway, and hence a more effective overall system.</span></p><p>To solve the energy mismatch between the components the team adopted a feedback loop between computational modeling and experimentation. Powerful computational tools enabled the design of a range of potential linking molecules to explore how they would influence the electronic coupling between the silicon nanocrystal (the solar panel) and the catalyst. This approach acted as a “chemical blueprint”, allowing them to predict which design would create the most well-aligned connection. The team then took these findings to the lab and synthesized the most promising candidates and tested their real-world performance, comparing them to the properties predicted by the models. The results confirmed the predications and demonstrated that a specific, directly bonded molecular bridge was the most effective design.</p><p><span>This work describes a foundational step in the search for fuels synthesized by light. By developing an approach for the fundamental challenge of aligning a solar collector and a CO<sub>2</sub> catalyst, the team has provided a critical design guideline for building more efficient and powerful devices in the future.&nbsp;</span></p><p>&nbsp;</p></div> </div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><hr><p>&nbsp;</p></div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><h3><strong>Supercharging Chemistry: A jump forward in light-driven chemistry</strong></h3><p>DOI: <a href="https://doi.org/10.1126/science.adw1648" rel="nofollow">https://doi.org/10.1126/science.adw1648</a></p><p class="lead"><em>New collaborative research involving RASEI Fellow Niels Damrauer, addresses one of the ‘house of cards’ problems sometimes critical in photoredox catalysis.</em></p><p>Think about how you build a house of cards, every time you add a new card, there is a chance the whole thing will fall apart. This is a challenge often faced by chemists when they are trying to put together the components needed for a light-driven reaction. While this type of chemistry has huge potential in making the chemistry cleaner and more efficient, one of the features that can cause the whole thing to fall apart is a phenomenon called back electron transfer, where the desired chemical reaction is reversed, wasting energy and limiting the kinds of reaction that can be performed.</p><p>This collaborative team that includes <a href="/rasei/niels-damrauers-rasei-engagement" rel="nofollow">RASEI Fellow Niels Damrauer</a> from Ҵýƽ and the groups of Garret Miyake and Robert Paton from Colorado State University in Fort Collins, has developed a new catalyst system that overcomes this fundamental obstacle. Published in a recent issue of Science, this work introduces a ‘super-reducing’ organic photoredox catalyst that, through preventing this backward reaction, opens the door to powerful new redox chemistries.</p><p>To better understand this discovery it is useful to think of the process like filling a bucket with water. In typical photoredox reactions, the bucket has a leak. As water is poured into the bucket (adding energy from light), some of it immediately drains out. This ‘leak’ is back electron transfer (BET), and it is especially problematic for complex and difficult reactions that require a lot of energy – it is like trying to fill a very leaky bucket with a very slow faucet.</p><p>The research collaboration, part of the National Science Foundation (NSF) funded Center for Chemical Innovation (CCI) Center for Sustainable Photoredox Catalysis (SuPRCat) took inspiration from nature to develop a solution for this problem. In photosynthesis plants use a process called proton-coupled electron transfer (PCET) to efficiently capture and store energy from sunlight, preventing energy loss. The team used a combination of sophisticated computational modeling and experimental investigation to design a catalyst that incorporates a similar mechanism. When the catalyst is energized by light it simultaneously transfers an electron to the target molecule and releases a proton (a hydrogen atom without its electron). This prevents the reaction from going backwards. This small change has a huge impact on how the reaction proceeds, it is essentially like patching the leak in the bucket as you pour the water in, ensuring that all the energy is used for the desired reaction.</p><p>As is often the case with research, the path to this discovery was not a straight line. The investigations initially focused on changing an existing catalyst framework. During these experiments they noticed that one of the new catalysts (PC40Me) was unexpectedly effective. The reduction of benzene is known to be a difficult transformation, but reactions catalyzed with PC40Me were possible. They found that under the reaction conditions PC40Me was transforming into a new chemical structure, and it was this new system that was efficient for the historically difficult reduction of benzene. Armed with this knowledge the team built new catalyst designs around the new structure, creating a more efficient catalyst (named PC8). PC8 is not only a ‘super reducer’ capable of reducing a broad range of aromatic compounds under mild conditions, it also proved to be extremely robust.</p><p>The key features of this work lies in its potential to be a new tool in how we design and build everything from pharmaceuticals to plastics. By providing a way to perform these difficult reduction reactions more efficiently and sustainably, this catalyst system has the potential to reduce waste and energy consumption. By opening the door to a transformation that has typically been thought of as difficult and un-efficient, it could act as an enabling technology in the synthesis of new classes of molecules that were previously out of reach.</p><p>This work highlights the power of collaboration. The combination of different tools and approaches that were required to complete this work would have been prohibitive for a single research group. By combining expertise the team were able to unravel this complex chemical puzzle, not only demonstrating a new transformation, but providing some design rules that can be used by future photocatalysis practitioners in reducing BET.&nbsp;</p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Damrauer_SuperReducer-01.png?itok=Vz9M-w8z" alt="figures from the paper showing the design of a new super charged photoredox catalyst" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><hr><p>&nbsp;</p></div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 2"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-content-media ucb-article-content-media-left col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Reid_Nickel-01.png?itok=glb3BT8z" alt="Figures from the paper showing how nickel chemistry is photochemically activated" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><h3><strong>Finding the On switch for more efficient light-driven chemistry</strong></h3><p>DOI: <a href="https://doi.org/10.1038/s41467-025-60729-x" rel="nofollow"><em>https://doi.org/10.1038/s41467-025-60729-x</em></a></p><p class="lead"><em>Collaboration led by RASEI members Obadiah Reid and Garry Rumbles solves a long-standing puzzle in important organic chemical transformation.</em></p><p>In the world of organic chemistry, making new molecules, the building blocks for everything from advanced electronic materials to pharmaceuticals, is a bit like being a chef. Chemists are always looking to improve the recipe, to make it faster, cheaper, more efficient, and produce less waste. In recent years one of the most exciting new ‘cooking techniques’ is nickel photocatalysis, which uses abundant, low-cost nickel and the power of light to enable chemists to build complex molecules under mild conditions.</p><p>This technique has emerged as something of a game-changer in building molecules, but it comes with a significant puzzle. The nickel catalyst, as it is normally added to a reaction, is in a dormant state (called a ‘pre-catalyst’). To get the reaction moving, the catalyst needs to be ‘woken up’. For years, scientists were not sure what the wake-up call was. The activation from pre-catalyst to the functioning catalyst was something of a black box, with numerous theories for what was happening. This led to the assumption that each reaction was unique, and each reaction required its own individual and complicated startup sequence. This has often required a lot of work to find the right ‘On switch’.</p><p>This collaborative study, led by RASEI researchers <a href="/rasei/obadiah-reids-rasei-engagement" rel="nofollow">Obadiah Reid</a> and <a href="/rasei/garry-rumbles-rasei-engagement" rel="nofollow">Garry Rumbles</a> at the National Renewable Energy Laboratory (NREL), brings together expertise from the SLAC National Accelerator Laboratory, Brookhaven National Laboratory, Argonne National Laboratory and Northeastern University. Together, the scientists have identified key features of the transformation from pre-catalyst to active catalyst. In the report, just published in Nature Communications, the team shows that there is a universal ‘On switch’ to start these powerful reactions, and the key to this transformation is light.</p><p>Imagine a high-tech machine delivered in a locked crate. You know that once you get it out and get it running, it can do amazing things, but you don’t have the key. For years, chemists were essentially trying to pick the lock in different ways every time they wanted to use it. This study describes a universal key for getting the crate open.</p><p>It was found that light, either directly, or transferred from another light-absorbing molecule, provide a jolt of energy that breaks a bond in the nickel pre-catalyst structure. This process, which is called photolysis, activates the nickel complex, getting it ready to do the chemistry. This initial step is something that has previously been proposed but never fully proven.</p><p>The team brought together a sophisticated array of tools to effectively investigate this mechanism, including incredibly fast laser systems that can watch chemical changes happen in fractions of a second. This allowed them to witness the ‘unlocking’ process in real-time and identify the exact sequence of events. They observed that after the initial light-induced bond breaking, the catalyst can then interact with molecules in the surrounding solvent, forming a temporary ‘reservoir’ that holds the catalyst in a state ready for the main reaction.</p><p>Building this body of evidence and developing these findings required a significant team effort, bringing together scientists from across the country, from multiple national labs and universities. RASEI Scientists at Ҵýƽ and NREL used advanced spectroscopy to track the catalyst’s behavior, while researchers at SLAC used high-powered X-rays to confirm changes in the structure of the nickel complex. This combination of knowledge and experience with cutting-edge instrumentation was essential in providing a complete understanding of these reactions begin.</p><p><span>Development of unified explanation for how one of the most important tools in an organic chemist’s toolbox is activated has important implications. Understanding this fundamental activation step allows chemists to move from guessing to designing. Not only does this support improvement in the activation of existing reactions, it also provides opportunities to design new transformations, all of which will streamline the manufacture of chemical commodities, such as pharmaceuticals and materials.</span></p></div> </div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><hr><p>&nbsp;</p></div> </div> </div> </div> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><h3><strong>Scientists move microscopic solar chemical factories out of water to unlock new transformations</strong></h3><p>DOI: <a href="https://doi.org/10.1039/D5SE00263J" rel="nofollow">https://doi.org/10.1039/D5SE00263J</a></p><p class="lead"><em>Four RASEI Fellows work together to expand the potential applications of nanoparticle photocatalysts</em></p><p>We all understand the power of the sun. We feel it on a hot summer’s day, we see it harnessed in solar panels that power our homes and cities. Chemical photocatalysis develops approaches to shrink that ability to harness this energy down to a molecular scale, and uses this energy to power chemical reaction, to power the building of important organic molecules, the foundations of pharmaceuticals, materials, and clean fuels.</p><p>One of the technologies used to harness light on the molecular level are a class of particles called organic nanoparticles (oNPs). Think of them as tiny, solar-powered factories, expertly designed to capture light and use its energy to drive chemical reactions. The oNPs are made from readily available earth-abundant materials, offering a cheap, clean, and sustainable alternative to a range of more traditional chemical reactions, which can often rely on rare, expensive metals that are hard to get hold of and can produce significant waste.</p><p>However, the oNPs, for all their potential as chemical factories, do have one significant limitation, they can only be built and operated in water. This is a fundamental roadblock. While water is essential for life, it is often a very poor environment for performing chemical reactions and can be very detrimental for the complex and delicate sequence of chemical transformations required for producing valuable products. The full power of these nano-factories was, quite literally, stuck in the water.</p><p>To understand this challenge, imagine that you have designed the world’s most efficient and powerful engine. It is a true engineering breakthrough, but it comes with a major catch, it can only run while completely submerged in the ocean. This is fine if you want to get around in a submarine, or a boat, but you can’t put it into a car, or a plane, or a generator on land, where you need it most. The potential of this new innovation is trapped, unable to be used for countless valuable applications.</p><p>That is similar to the situation faced by the researchers, led by RASEI Fellows <a href="/rasei/stephen-barlows-rasei-engagement" rel="nofollow">Stephen Barlow</a>, <a href="/rasei/seth-marder-rasei-engagement" rel="nofollow">Seth Marder</a>, <a href="/rasei/obadiah-reids-rasei-engagement" rel="nofollow">Obadiah Reid</a> and <a href="/rasei/garry-rumbles-rasei-engagement" rel="nofollow">Garry Rumbles</a>. The oNPs were confined to water-based reaction media, in order to realize their full potential the team needed to find a way to move these delicate ‘nano-factories’ from water to the ‘dry-land’ of other chemical environments, known as non-aqueous solvents, without the oNPs collapsing or breaking down.</p><p>This study describes a solution that the team developed. They devised a multi-step process to gently coax the oNPs out of their native water environment and prepare them to operate in different chemical solvents.</p><p>The process they developed is analogous to making salad dressing in the kitchen. It begins by mixing the water containing the nanoparticles with an oily substance (in this study oleic acid) and shaking it. This creates an emulsion, where tiny droplets of water are suspended in the oil, much like a vinaigrette. During this process the oNPs leave the water and move into the oil, which wraps around them like a protective coating. Finally the water is gently remove, leaving the oNPs safely suspended in their new oily environment. The protective layer formed around them allows them to be seamlessly transferred to a range of new non-aqueous solvents, ready to get to work.</p><p>A key part of this study was demonstrating that the oNP ‘factories’ were still functional after their transfer to new solvent systems. Using a suite of tools the team were able to confirm that the transferred oNPs could still absorb light and perform the chemical reactions.</p><p>With these findings the potential of the oNPs can be explored and expanded. It reveals new opportunities, not only in putting together organic molecules, but also in the synthesis of clean fuels, such as hydrogen.&nbsp;<span>&nbsp;</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Reid_water-01%20%281%29.jpg?itok=bH-hcPfZ" alt="Figures from the paper on moving nanoparticles into non-aqueous reaction media" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div> <div>September 2025</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div> <div class="imageMediaStyle large_image_style"> <img loading="lazy" src="/rasei/sites/default/files/styles/large_image_style/public/2025-10/2025_10_Light_hero.jpg?itok=7Nb9PNeI" width="1500" height="328" alt="Illustration of a reaction vessel in a light reactor"> </div> </div> <div>On</div> <div>White</div> Tue, 30 Sep 2025 15:11:48 +0000 Daniel Morton 1397 at /rasei Catalyst, Base, Additives, and Solvent: The Tools to Dig a Better CANAL Reaction /rasei/2025/08/08/catalyst-base-additives-and-solvent-tools-dig-better-canal-reaction <span>Catalyst, Base, Additives, and Solvent: The Tools to Dig a Better CANAL Reaction</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-08-08T19:51:40-06:00" title="Friday, August 8, 2025 - 19:51">Fri, 08/08/2025 - 19:51</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-10/2025_08_08_JOC_Thumbnail.png?h=d95abdc4&amp;itok=zQh2-IoT" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/43"> Publication </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/280" hreflang="en">Computational Modeling</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/269" hreflang="en">Energy Applications</a> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> </div> </div> </div> </div> <div>JOURNAL OF ORGANIC CHEMISTRY, 2025, 90, 33, 11870-11882</div> <script> window.location.href = `https://doi.org/10.1021/acs.joc.5c01281`; </script> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Sat, 09 Aug 2025 01:51:40 +0000 Daniel Morton 1412 at /rasei Light-powered reactions could make the chemical manufacturing industry more energy-efficient /rasei/2025/06/26/light-powered-reactions-could-make-chemical-manufacturing-industry-more-energy-efficient <span>Light-powered reactions could make the chemical manufacturing industry more energy-efficient</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-06-26T16:25:34-06:00" title="Thursday, June 26, 2025 - 16:25">Thu, 06/26/2025 - 16:25</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-06/2025_06_TheConversationPhotoCat_Thumbnail.png?h=2469e47b&amp;itok=MCRA4_1D" width="1200" height="800" alt="Sunshine"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/259"> Media Engagement </a> <a href="/rasei/taxonomy/term/177"> News </a> <a href="/rasei/taxonomy/term/170"> Publication Highlight </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/269" hreflang="en">Energy Applications</a> <a href="/rasei/taxonomy/term/350" hreflang="en">SUPRCAT</a> </div> <a href="/rasei/our-community">Daniel Morton</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> <div><div class="feature-layout-callout feature-layout-callout-large"><div class="ucb-callout-content"><div class="ucb-box ucb-box-title-left ucb-box-alignment-none ucb-box-style-fill ucb-box-theme-lightgray"><div class="ucb-box-inner"><div class="ucb-box-title">Show me more!</div><div class="ucb-box-content"><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-full ucb-link-button-large" href="https://theconversation.com/light-powered-reactions-could-make-the-chemical-manufacturing-industry-more-energy-efficient-257796" rel="nofollow"><span class="ucb-link-button-contents">The Conversation Highlight</span></a></p><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-full ucb-link-button-large" href="/rasei/suprcat" rel="nofollow"><span class="ucb-link-button-contents">SuPRCat</span></a></p><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-full ucb-link-button-large" href="https://doi.org/10.1126/science.adw1648" rel="nofollow"><span class="ucb-link-button-contents">Research Article</span></a></p><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-large ucb-link-button-full" href="https://www.chemistryworld.com/news/super-reducing-photoredox-catalyst-paves-a-new-way-for-arene-reduction/4021763.article" rel="nofollow"><span class="ucb-link-button-contents">Chemistry World Highlight</span></a></p><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-large ucb-link-button-full" href="/asmagazine/2025/07/08/lightbulb-represents-more-just-good-idea" rel="nofollow"><span class="ucb-link-button-contents">Colorado Arts &amp; Sciences Magazine Highlight</span></a></p></div></div></div></div></div><p>A recent collaborative report, published in Science, including RASEI Fellow Niels Damrauer, addresses a key issue for light-driven chemistry, potentially opening up possibilities for future energy-efficient chemical manufacturing.</p><p>Chemical reactions typically require an input of energy to proceed, this can be through heating, or introduction of chemical energy in the form of reactive chemicals. Recently, light-driven chemistry has emerged as a more energy efficient alternative. The principle is to use energy from light, which is absorbed by a catalyst. Excited by the light energy the catalyst can then donate an electron to the chemicals undergoing the desired chemical transformation.</p><p>This sounds great – light-driven reactions? One of the key issues in this class of chemistry is back transfer of the electron. This means that after the catalyst donates the electron to the reagents, instead of doing the desired reaction, the reagent gives the electron back to the catalyst. This can significantly slow down the desired reaction, even sometimes shutting it down.</p><p>This report details a new type of catalyst that can overcome this back transfer of electrons. Through rationale design of the catalyst the new system uses a chemical reaction as a catch, preventing the back transfer from the reagent and strongly favoring the desired reaction.</p><p>To highlight the impact of this work, which was completed as part of the NSF Center for Chemical Innovation Center for Sustainable Photoredox Catalysis (SuPRCat), Ҵýƽ student Arindam Sau, a member of the Damrauer group, teamed up with a graduate student and postdoc from Colorado State University to put together a review and summary of this work that was recently published in The Conversation. Check out the highlight to get a full picture of the impact of this work.&nbsp;<span>&nbsp;</span></p></div> </div> </div> </div> </div> <div>June 2025</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div> <div class="imageMediaStyle large_image_style"> <img loading="lazy" src="/rasei/sites/default/files/styles/large_image_style/public/2025-06/2025_06_TheConversationPhotoCat_Hero.png?itok=q7xSJC5u" width="1500" height="323" alt="Sunshine"> </div> </div> <div>On</div> <div>White</div> Thu, 26 Jun 2025 22:25:34 +0000 Daniel Morton 1331 at /rasei Efficient super-reducing organic photoredox catalysis with proton-coupled electron transfer mitigated back electron transfer /rasei/2025/06/19/efficient-super-reducing-organic-photoredox-catalysis-proton-coupled-electron-transfer <span>Efficient super-reducing organic photoredox catalysis with proton-coupled electron transfer mitigated back electron transfer</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-06-19T11:38:42-06:00" title="Thursday, June 19, 2025 - 11:38">Thu, 06/19/2025 - 11:38</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-08/2025_06_19_Science_Thumbnail.png?h=d3502f1d&amp;itok=YmGeP1kL" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/43"> Publication </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/280" hreflang="en">Computational Modeling</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/269" hreflang="en">Energy Applications</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/350" hreflang="en">SUPRCAT</a> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> </div> </div> </div> </div> <div>SCIENCE, 2025, 388, 6753, 1294-1300</div> <script> window.location.href = `https://doi.org/10.1126/science.adw1648`; </script> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Thu, 19 Jun 2025 17:38:42 +0000 Daniel Morton 1350 at /rasei Supercharging Chemistry: A jump forward in light-driven chemistry /rasei/2025/06/07/supercharging-chemistry-jump-forward-light-driven-chemistry <span>Supercharging Chemistry: A jump forward in light-driven chemistry</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-06-07T10:28:32-06:00" title="Saturday, June 7, 2025 - 10:28">Sat, 06/07/2025 - 10:28</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-08/2025_06_19_Science_Thumbnail.png?h=d3502f1d&amp;itok=YmGeP1kL" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/177"> News </a> <a href="/rasei/taxonomy/term/170"> Publication Highlight </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/385" hreflang="en">RoundupPhotocatalysis</a> </div> <a href="/rasei/our-community">Daniel Morton</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><div class="feature-layout-callout feature-layout-callout-medium"><div class="ucb-callout-content"><div class="ucb-box ucb-box-title-left ucb-box-alignment-none ucb-box-style-fill ucb-box-theme-lightgray"><div class="ucb-box-inner"><div class="ucb-box-title">Find out more</div><div class="ucb-box-content"><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-full ucb-link-button-large" href="https://doi.org/10.1126/science.adw1648" rel="nofollow"><span class="ucb-link-button-contents">Read the Article</span></a></p></div></div></div></div></div><p class="lead"><em><strong>New collaborative research involving RASEI Fellow Niels Damrauer, addresses one of the ‘house of cards’ problems sometimes critical in photoredox catalysis.</strong></em></p><p>Think about how you build a house of cards, every time you add a new card, there is a chance the whole thing will fall apart. This is a challenge often faced by chemists when they are trying to put together the components needed for a light-driven reaction. While this type of chemistry has huge potential in making the chemistry cleaner and more efficient, one of the features that can cause the whole thing to fall apart is a phenomenon called back electron transfer, where the desired chemical reaction is reversed, wasting energy and limiting the kinds of reaction that can be performed.</p><p>This collaborative team that includes <a href="/rasei/niels-damrauers-rasei-engagement" rel="nofollow">RASEI Fellow Niels Damrauer</a> from Ҵýƽ and the groups of Garret Miyake and Robert Paton from Colorado State University in Fort Collins, has developed a new catalyst system that overcomes this fundamental obstacle. Published in a recent issue of Science, this work introduces a ‘super-reducing’ organic photoredox catalyst that, through preventing this backward reaction, opens the door to powerful new redox chemistries.</p><p>To better understand this discovery it is useful to think of the process like filling a bucket with water. In typical photoredox reactions, the bucket has a leak. As water is poured into the bucket (adding energy from light), some of it immediately drains out. This ‘leak’ is back electron transfer (BET), and it is especially problematic for complex and difficult reactions that require a lot of energy – it is like trying to fill a very leaky bucket with a very slow faucet.</p><p>The research collaboration, part of the National Science Foundation (NSF) funded Center for Chemical Innovation (CCI) Center for Sustainable Photoredox Catalysis (SuPRCat) took inspiration from nature to develop a solution for this problem. In photosynthesis plants use a process called proton-coupled electron transfer (PCET) to efficiently capture and store energy from sunlight, preventing energy loss. The team used a combination of sophisticated computational modeling and experimental investigation to design a catalyst that incorporates a similar mechanism. When the catalyst is energized by light it simultaneously transfers an electron to the target molecule and releases a proton (a hydrogen atom without its electron). This prevents the reaction from going backwards. This small change has a huge impact on how the reaction proceeds, it is essentially like patching the leak in the bucket as you pour the water in, ensuring that all the energy is used for the desired reaction.</p><p>As is often the case with research, the path to this discovery was not a straight line. The investigations initially focused on changing an existing catalyst framework. During these experiments they noticed that one of the new catalysts (PC40Me) was unexpectedly effective. The reduction of benzene is known to be a difficult transformation, but reactions catalyzed with PC40Me were possible. They found that under the reaction conditions PC40Me was transforming into a new chemical structure, and it was this new system that was efficient for the historically difficult reduction of benzene. Armed with this knowledge the team built new catalyst designs around the new structure, creating a more efficient catalyst (named PC8). PC8 is not only a ‘super reducer’ capable of reducing a broad range of aromatic compounds under mild conditions, it also proved to be extremely robust.</p><p>The key features of this work lies in its potential to be a new tool in how we design and build everything from pharmaceuticals to plastics. By providing a way to perform these difficult reduction reactions more efficiently and sustainably, this catalyst system has the potential to reduce waste and energy consumption. By opening the door to a transformation that has typically been thought of as difficult and un-efficient, it could act as an enabling technology in the synthesis of new classes of molecules that were previously out of reach.</p><p><span>This work highlights the power of collaboration. The combination of different tools and approaches that were required to complete this work would have been prohibitive for a single research group. By combining expertise the team were able to unravel this complex chemical puzzle, not only demonstrating a new transformation, but providing some design rules that can be used by future photocatalysis practitioners in reducing BET.</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Damrauer_SuperReducer-01.png?itok=Vz9M-w8z" alt="figures from the paper showing the design of a new super charged photoredox catalyst" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div> <div>JUNE 2025</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Sat, 07 Jun 2025 16:28:32 +0000 Daniel Morton 1401 at /rasei Unfiltered Broadband Probes Can Obscure Long Time Dynamics in Populations Engaged in Second-Order Processes Including Annihilation /rasei/2025/03/03/unfiltered-broadband-probes-can-obscure-long-time-dynamics-populations-engaged-second <span>Unfiltered Broadband Probes Can Obscure Long Time Dynamics in Populations Engaged in Second-Order Processes Including Annihilation</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-03-03T15:52:55-07:00" title="Monday, March 3, 2025 - 15:52">Mon, 03/03/2025 - 15:52</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2025-03/2025_03_03_JPhysChemLet.png?h=d3502f1d&amp;itok=P8ACQoWc" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/43"> Publication </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/280" hreflang="en">Computational Modeling</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/269" hreflang="en">Energy Applications</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> </div> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default"> <div class="ucb-article-text" itemprop="articleBody"> </div> </div> </div> </div> <div>THE JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2025, 16, 2522-2528</div> <script> window.location.href = `https://doi.org/10.1021/acs.jpclett.5c00197`; </script> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Mon, 03 Mar 2025 22:52:55 +0000 Daniel Morton 1249 at /rasei Shining new light on an old problem: Breaking down ‘Forever Chemicals’ and building the next generation of materials /rasei/2025/01/15/shining-new-light-old-problem-breaking-down-forever-chemicals-and-building-next <span>Shining new light on an old problem: Breaking down ‘Forever Chemicals’ and building the next generation of materials</span> <span><span>Daniel Morton</span></span> <span><time datetime="2025-01-15T10:04:08-07:00" title="Wednesday, January 15, 2025 - 10:04">Wed, 01/15/2025 - 10:04</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/rasei/sites/default/files/styles/focal_image_wide/public/2024-11/2024_11_20_Nature.png?h=e2bcc475&amp;itok=0daxMYH7" width="1200" height="800" alt="TOC Graphic"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/rasei/taxonomy/term/177"> News </a> <a href="/rasei/taxonomy/term/170"> Publication Highlight </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/rasei/taxonomy/term/281" hreflang="en">Catalysis</a> <a href="/rasei/taxonomy/term/163" hreflang="en">Damrauer</a> <a href="/rasei/taxonomy/term/274" hreflang="en">Nanoscience and Advanced Materials</a> <a href="/rasei/taxonomy/term/385" hreflang="en">RoundupPhotocatalysis</a> </div> <a href="/rasei/our-community">Daniel Morton</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><div class="feature-layout-callout feature-layout-callout-medium"><div class="ucb-callout-content"><div class="ucb-box ucb-box-title-left ucb-box-alignment-none ucb-box-style-fill ucb-box-theme-lightgray"><div class="ucb-box-inner"><div class="ucb-box-title">Find out more</div><div class="ucb-box-content"><p><a class="ucb-link-button ucb-link-button-blue ucb-link-button-full ucb-link-button-large" href="https://doi.org/10.1038/s41586-024-08327-7" rel="nofollow"><span class="ucb-link-button-contents">Read the Article</span></a></p></div></div></div></div></div><p class="lead"><em>Using a new catalyst and visible light, researchers have developed a chemical “scalpel” to degrade persistent pollutants and enable new, more precise chemical reactions.</em></p><p>The global challenge of “forever chemicals” has made the headlines for years. The carbon-fluorine (C–F) bond is one of the strongest in all of chemistry. For decades the sheer strength of the C–F bond has been a blessing and a curse. This incredible strength is what makes “forever chemicals”, like PFAS, so stable and useful in everything from non-stick pans to waterproof clothing but is also the reason that they are nearly impossible to break down. This has been a major contributor to the growing plastic waste crisis, and a key reasons for these compounds to be now known as one of the hardest pollutants to remove from the environment. A recent collaborative study, including <a href="/rasei/niels-damrauers-rasei-engagement" rel="nofollow">RASEI Fellow Niels Damrauer</a>, has a new solution for this problem. Development of a new catalyst that acts like a chemical scalpel, using blue light to precisely sever this famously inert bond. This approach not only offers a new way to degrade these persistent pollutants but also opens the door to using what were previously considered unreactive fluorinated molecules as building blocks for new chemical transformations and products.</p><p>This study is an illustrative example of a modern, collaborative approach to chemical innovation, as part of the NSF funded Center for Sustainable Photoredox Catalysis (<a href="/rasei/suprcat" rel="nofollow">SuPRCat</a>). The research team came at the problem from two different angles: computational modeling and hands-on experimentation. The computational chemists first used powerful simulations to design and predict the behavior of a new organic catalyst. This helped them understand exactly how the catalyst could use low-energy, visible blue light to act as our "chemical scalpel," targeting and breaking the C–F bonds without the need for intense heat.</p><p>With this knowledge, the experimental chemists then created the catalyst in the lab. They showed that it could precisely snip the C-F bonds in a variety of molecules, demonstrating it was capable of both degrading persistent pollutants like PFAS and building new chemical structures that were previously difficult to construct.</p><p><span>The success of this research with a simple, abundant energy source like visible light shows that chemical reactions don’t have to be energy intensive. This research describes the power of precise, light-driven chemistry. By designing a catalyst that can target and activate some of the toughest bonds in chemistry, this team has not only revealed a potential path forward for degrading PFAS, but also demonstrated a new tool for chemists to build molecules in a cleaner and more energy efficient way.</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default ucb-article-media-paragraph"> <figure class="ucb-paragraph-media__image"> <img class="ucb-article-media-img ucb-article-media-img--original" src="/rasei/sites/default/files/styles/original_image_size/public/2025-10/Damrauer_PFAS-01.png?itok=XwEOQVzU" alt="Figures from the paper, including functionalization and decomposition of PFAS chemicals" loading="lazy"> <figcaption class="ucb-paragraph-media__caption" style="text-align: left;"> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div> <div>JANUARY 2025</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Wed, 15 Jan 2025 17:04:08 +0000 Daniel Morton 1398 at /rasei